Road safety problems that cause loss of human lives exist all over the world. Latin America does not escape this, which leads to the need to strengthen the actions carried out both by the State and by the private sector and NGOs. The Second Decade of Action for Road Safety and the United Nations Sustainable Development Goals call and guide countries on the actions that can be carried out to achieve the desired goals for 2030. In recent years, various countries in the region have made numerous efforts to improve mortality rates due to traffic accidents. In this way, it is possible to find successful examples that can be replicated and that show that it is possible to achieve significant changes and improvements in terms of safe mobility in our countries. This document presents some of the many actions carried out in the Region that prove this. The challenge is to manage to articulate comprehensive actions within the framework of programs sustained over time that implement the necessary actions in all the necessary fields.