Muestra métricas de impacto externas asociadas a la publicación. Para mayor detalle:
| Indexado |
|
||
| DOI | 10.5867/MEDWAVE.2021.11.8184 | ||
| Año | 2021 | ||
| Tipo |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
INTRODUCTION Brain metastases are a frequent problem in cancer patients, especially in lung cancer. The usual treatment for brain oligometastasis is holobrain radiotherapy. Given the persistent poor prognosis of this disease, other therapeutic alternatives such as radiosurgery have been proposed. However, there is no clarity regarding the effectiveness of its addition. METHODS We conducted a search in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple sources of information, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the identified reviews, analyzed data from the primary studies, performed a meta-analysis, and prepared a summary table of results using the GRADE method. RESULTS AND CONCLUSIONS We identified 17 systematic reviews that together included seven primary studies, four of which correspond to randomized trials. All trials evaluated patients with brain metastases, but none specifically evaluated the lung cancer population. We conclude that it is not possible to clearly establish whether radiosurgery reduces the deterioration of neurological functionality, cognitive impairment, mortality, or serious adverse effects, because the certainty of the existing evidence has been assessed as very low.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Antúnez, Gabriela | - |
Facultad de Medicina - Chile
|
| 2 | Merino, Tomás | - |
Epistemonikos Foundation - Chile
Facultad de Medicina - Chile |