Introduction: Antineoplastic treatments generate different sequelae in the pediatric oncology patient, the factors that influence the appearance of cognitive sequelae are associated with the patient's age, the type of neoplasia, characteristics of the treatment implemented and doses used, among other factors. Cognitive sequelae may not be evident at the end of treatment and are silent consequences that sometimes become visible when the patient enters the educational establishment, due to the demand for school activities that require the implementation of cognitive resources. Thus, cognitive sequelae in pediatric oncology constitute a risk factor for the acquisition of learning and the inclusion of patients when they return to school. Objective: To describe the process of intervention in executive functions in a patient diagnosed with a central nervous system tumor, as well as the multidisciplinary approach to cognitive sequelae. Case presentation: Male patient enters the Oncology Rehabilitation Center of the Our Children's Foundation (CROFNH) in August 2016, at the age of 5 years, 7 months, with a diagnosis of Central Nervous System Tumor (Tu SNC) in the third ventricle. She starts rehabilitation with multidisciplinary team that included: physiatrist physician, kinesiology, occupational therapy, differential education, phonoaudiology and neuropsychology. Conclusions: The long-term manifestation of cognitive functions highlights the importance of monitoring the cognitive profile at each new stage of neurodevelopment and detecting intervention needs in order to provide patients with the best conditions for them to have an optimal quality of life