Despite lithium (Li) rich brines in salt flats often being associated with geothermal systems, most salt flats do not have an active present-day geothermal system to evaluate this association, making this association somewhat speculative. However, a salt flat in the Chilean Andes with a hypersaline lake - Laguna Verde (LV) - within a closed basin encircled by a series of volcanoes, an active geothermal system with surface manifestations, and outcrops of the potential Li source rocks, provides an excellent opportunity for this evaluation. The study area has outcrops of mostly andesitic-dacitic rocks with the limited occurrence of rhyolitic rocks (sequences with ignimbrites and glass-rich ash), reported in the boreholes drilled in the area for mineral exploration. From these lithologies (primary sources), Li is released through leaching by geothermal fluids, active intermittently from the Miocene to the present day. The LV geothermal system consists of an outflow zone on the lake's southern margin, where more than 20 hot springs with temperatures up to 47°C are located. This system's upflow area is 25 km SSW of LV, represented by fumaroles located in the Nevado Ojos del Salado volcano's central crater. The considerable distance between upflow and outflow zones (i.e., the geothermal system's extension) is likely to cause requilibration(s) during the long-distance travel of thermal water, leading to underestimation of reservoir temperature (85 and 90°C with Na-K-Mg and silica geothermometers, respectively). Whereas Li concentration in the hot springs is 2.76 to 4.46 mg/L, in Peñas Blancas River that feeds LV after passing through the volcanic environment (rocks rich in Li), thus getting enriched in Li, it is 0.59 to 0.76 mg/L. Li contribution over six times the non-thermal water envisages the importance of the thermal waters in Li release and transport from the source rock to its eventual concentration in LV.