Introduction: Absenteeism due to occupational diseases has an impact on the economy and has been responsible for the challenge of the worker’s reintegration into their work context. From the foregoing, work reintegration programs for occupational diseases are of growing interest. Objective: To identify the main results and characteristics of interventions for the labor reintegration of workers on medical leave due to musculoskeletal and mental health diseases. Material and Methods: Qualitative systematic review. The databases used were Cochrane Central Register of Controlled Trials, MEDLINE / PubMed and the Epistemonikos database. Results: 36.8% of the interventions presented statistically significant relationships. Characteristics of the interventions were disease-focused treatments, workplace interventions, and planning with the employer for return to work. Conclusions: Interventions that articulate actions with workers, in the workplace and with employers, could increase return to work.