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Early living donor liver transplantation for alcohol-associated hepatitis
Indexado
WoS WOS:001002387800001
Scopus SCOPUS_ID:85152939991
DOI 10.1016/J.AOHEP.2023.101098
Año 2023
Tipo artículo de investigación

Citas Totales

Autores Afiliación Chile

Instituciones Chile

% Participación
Internacional

Autores
Afiliación Extranjera

Instituciones
Extranjeras


Abstract



Introduction and Objectives: Lately, there has been a steady increase in early liver transplantation for alcohol-associated hepatitis (AAH). Although several studies have reported favorable outcomes with cadaveric early liver transplantation, the experiences with early living donor liver transplantation (eLDLT) are limited. The primary objective was to assess one-year survival in patients with AAH who underwent eLDLT. The secondary objectives were to describe the donor characteristics, assess the complications following eLDLT, and the rate of alcohol relapse. Materials and Methods: This single-center retrospective study was conducted at AIG Hospitals, Hyderabad, India, between April 1, 2020, and December 31, 2021. Results: Twenty-five patients underwent eLDLT. The mean time from abstinence to eLDLT was 92.4 ± 42.94 days. The mean model for end-stage liver disease and discriminant function score at eLDLT were 28.16 ± 2.89 and 104 ± 34.56, respectively. The mean graft-to-recipient weight ratio was 0.85 ± 0.12. Survival was 72% (95%CI, 50.61–88) after a median follow-up of 551 (23-932) days post-LT. Of the 18 women donors,11 were the wives of the recipient. Six of the nine infected recipients died: three of fungal sepsis, two of bacterial sepsis, and one of COVID-19. One patient developed hepatic artery thrombosis and died of early graft dysfunction. Twenty percent had alcohol relapse. Conclusions: eLDLT is a reasonable treatment option for patients with AAH, with a survival of 72% in our experience. Infections early on post-LT accounted for mortality, and thus a high index of suspicion of infections and vigorous surveillance, in a condition prone to infections, are needed to improve outcomes.

Revista



Revista ISSN
Annals Of Hepatology 1665-2681

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Disciplinas de Investigación



WOS
Gastroenterology & Hepatology
Scopus
Hepatology
SciELO
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Publicaciones WoS (Ediciones: ISSHP, ISTP, AHCI, SSCI, SCI), Scopus, SciELO Chile.

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Autores - Afiliación



Ord. Autor Género Institución - País
1 Kulkarni, Anand V. Hombre AIG Hospitals - India
AIG Hosp - India
2 Reddy, Raghuram - AIG Hospitals - India
AIG Hosp - India
3 Arab, Juanpablo Hombre Escuela de Medicina - Chile
Pontificia Universidad Católica de Chile - Chile
4 Sharma, Mithun - AIG Hospitals - India
AIG Hosp - India
5 Shaik, Sameer - AIG Hospitals - India
AIG Hosp - India
6 Iyengar, Sowmya - AIG Hospitals - India
AIG Hosp - India
7 Kumar, Naveen Hombre AIG Hospitals - India
AIG Hosp - India
8 Sabreena - AIG Hospitals - India
8 Sabreena - AIG Hospitals - India
8 Sabreena - AIG Hospitals - India
8 Sabreena - AIG Hospitals - India
8 Sabreena - AIG Hospitals - India
8 Sabreena - AIG Hospitals - India
8 Sabreena - AIG Hospitals - India
8 Sabreena - AIG Hospitals - India
8 Sabreena - AIG Hospitals - India
8 Sabreena - AIG Hospitals - India
8 Sabreena - AIG Hospitals - India
9 Gupta, Rajesh - AIG Hospitals - India
AIG Hosp - India
10 Premkumar, Giri Vishwanathan - AIG Hospitals - India
AIG Hosp - India
11 Menon, Balachandran Palat - AIG Hospitals - India
AIG Hosp - India
12 Reddy, D. Nageshwar - AIG Hospitals - India
AIG Hosp - India
13 Rao, P. Nagaraja - AIG Hospitals - India
AIG Hosp - India
14 Reddy, K. Rajender - University of Pennsylvania - Estados Unidos
UNIV PENN - Estados Unidos

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Financiamiento



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