Deafness is one of the most frequent birth defects reaching up to 50% of population older than 70 years old. The main reason of the hearing loss is the damage in the hair cells (HC), which transform acoustic mechanical waves into electrochemical signals that run the auditory pathway towards the brain cortex. This cells located in the organ of Corti (OC) don't have regenerative capacity, reason why when they are severely affected the damage is irreversible and deafness is produced. Nevertheless there is a window of time when exists a regenerative potential where OC cells can be reprogrammed with regenerative purposes. Taking this into account, there are different methods to regenerate or replace the HC or the supporting cells that surround them. Therapies as the injection of Stem Cells into the inner ear, the manipulation of genes that participates in the cell cycle exit for proliferation induction and trans-differentiation of the SC have been tested with variable success that is reviewed. Spite of that, more research should be conducted in order to get a more spread, reliable and stable regenerative response.