Although the number of empirical studies on prison inmates in Latin America has increased in recent years, an aspect that still remains little studied is the situation of prison workers. This article analyzes the labor situation of prison officers in Latin America, and considers their working conditions, quality of life and the problems that affect them, in a region marked by precarious, overcrowded and violent prison systems. To do so, a systematic review of articles published in Spanish or Portuguese on the Scielo platform between 2000-2021 was carried out. Our main findings show that prison officers suffer from significant levels of stress and work overload; and carry out their work in poor conditions; with long working hours; performing an invisible and socially undervalued job; with important risks of negative consequences for their physical and mental health. Finally, some implications of the findings and some lines of intervention are discussed.