Several research projects have revealed the importance of circadian light in the health and well-being of people. Most of these studies have been carried out in extreme regions, with a lack of daylight. However, this has led to greater awareness of the non-visual effects of light and the importance of lighting designs that consider principles that generate circadian activation in all contexts, including the Global South. The main objective of this chapter is to analyze the lighting conditions and to know the circadian stimulation potential for offices that lack windows for daylight and are only illuminated with artificial lighting, where a low circadian impact is assumed. The results indicate that in offices that were not intentionally planned to comply with the characteristics of the circadian stimulus, it is not possible to achieve it just by having lamps with a color temperature between 3000 to 6500 K, but it is necessary to have horizontal illuminance levels above 300 lx and evaluate the vertical illuminance that the occupant has, when designing. It is necessary to move towards a more integrated design, focusing on workplaces without access to daylight.