This article explores the local repercussions of the Bishop of Charcas Alonso Granero de Avalos during his rule between 1578 and 1585. Through the memorial of the clergyman Bartolome Alvarez (1588), highlighting the economic activities of the prelate and the tax measures that he established on the diocesan clergy. This trend, in turn, impacted on indigenous parishes as a source of products and labor. From the denunciation and life of Alvarez, it is proposed how the prelate's government impacted on the trajectory of the clergy, the unleashed conflicts and the local responses.