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| DOI | 10.1038/S41598-018-29538-9 | ||||
| Año | 2018 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
The search for biomarkers of neurodegenerative diseases via fMRI functional connectivity (FC) research has yielded inconsistent results. Yet, most FC studies are blind to non-linear brain dynamics. To circumvent this limitation, we developed a "weighted Symbolic Dependence Metric" (wSDM) measure. Using symbolic transforms, we factor in local and global temporal features of the BOLD signal to weigh a robust copula-based dependence measure by symbolic similarity, capturing both linear and non-linear associations. We compared this measure with a linear connectivity metric (Pearson's R) in its capacity to identify patients with behavioral variant frontotemporal dementia (bvFTD) and controls based on resting-state data. We recruited participants from two international centers with different MRI recordings to assess the consistency of our measure across heterogeneous conditions. First, a seed-analysis comparison of the salience network (a specific target of bvFTD) and the default-mode network (as a complementary control) between patients and controls showed that wSDM yields better identification of resting-state networks. Moreover, machine learning analysis revealed that wSDM yielded higher classification accuracy. These results were consistent across centers, highlighting their robustness despite heterogeneous conditions. Our findings underscore the potential of wSDM to assess fMRI-derived FC data, and to identify sensitive biomarkers in bvFTD.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Moguilner, Sebastian | Hombre |
Universidad Favaloro - Argentina
Fdn Escuela Med Nucl FUESMEN - Argentina CNEA - Argentina Univ Nacl Cuyo UNCuyo - Argentina Comision Nacional de Energia Atomica Argentina - Argentina Instituto Balseiro - Argentina Favaloro Univ - Argentina |
| 2 | Garcia, Adolfo M. | Hombre |
Universidad Favaloro - Argentina
Comision Nacional de Investigacion Cientifica y Tecnologica - Argentina Natl Univ Cuyo UNCuyo - Argentina Consejo Nacional de Investigaciones Científicas y Técnicas - Argentina Universidad Nacional de Cuyo - Argentina Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Argentina Favaloro Univ - Argentina |
| 3 | Mikulan, Ezequiel | Hombre |
Universidad Favaloro - Argentina
Comision Nacional de Investigacion Cientifica y Tecnologica - Argentina Consejo Nacional de Investigaciones Científicas y Técnicas - Argentina Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Argentina Favaloro Univ - Argentina |
| 4 | Hesse, Eugenia | Mujer |
Universidad Favaloro - Argentina
Comision Nacional de Investigacion Cientifica y Tecnologica - Argentina UNIV BUENOS AIRES - Argentina Consejo Nacional de Investigaciones Científicas y Técnicas - Argentina Universidad de Buenos Aires - Argentina Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Argentina Favaloro Univ - Argentina |
| 5 | Garcia Cordero, Indira | Mujer |
Universidad Favaloro - Argentina
Comision Nacional de Investigacion Cientifica y Tecnologica - Argentina Consejo Nacional de Investigaciones Científicas y Técnicas - Argentina Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Argentina Favaloro Univ - Argentina |
| 6 | Melloni, Margherita | Mujer |
Universidad Favaloro - Argentina
Comision Nacional de Investigacion Cientifica y Tecnologica - Argentina Consejo Nacional de Investigaciones Científicas y Técnicas - Argentina Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Argentina Favaloro Univ - Argentina |
| 7 | Cervetto, Sabrina | Mujer |
Universidad Favaloro - Argentina
UNIV REPUBLICA - Uruguay Universidad La República - Uruguay Universidad de la República - Uruguay Favaloro Univ - Argentina |
| 8 | Serrano, Cecilia M. | Mujer |
Hosp Cesar Milstein - Argentina
|
| 9 | Herrera, Eduar | - |
Universidad Favaloro - Argentina
Comision Nacional de Investigacion Cientifica y Tecnologica - Argentina Univ Icesi - Colombia Consejo Nacional de Investigaciones Científicas y Técnicas - Argentina Universidad Icesi - Colombia Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Argentina Favaloro Univ - Argentina |
| 10 | REYES-LOBAO TELLO, PABLO RICARDO | Hombre |
Pontificia Univ Javeriana - Colombia
Hospital Universitario San Ignacio - Colombia |
| 11 | Matallana, Diana L. | Mujer |
Pontificia Univ Javeriana - Colombia
Hospital Universitario San Ignacio - Colombia |
| 12 | MANES, FACUNDO FRANCISCO | Hombre |
Universidad Favaloro - Argentina
Comision Nacional de Investigacion Cientifica y Tecnologica - Argentina Australian Res Council - Australia Consejo Nacional de Investigaciones Científicas y Técnicas - Argentina Australian Research Council (ARC) - Australia Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Argentina ARC Centre of Excellence in Cognition and its Disorders - Australia Favaloro Univ - Argentina |
| 13 | LEGAZ, AGUSTINA | Mujer |
Universidad Favaloro - Argentina
Comision Nacional de Investigacion Cientifica y Tecnologica - Argentina Australian Res Council - Australia Universidad Adolfo Ibáñez - Chile Univ Autonoma Caribe - Colombia Consejo Nacional de Investigaciones Científicas y Técnicas - Argentina Australian Research Council (ARC) - Australia Universidad Autónoma del Caribe - Colombia Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Argentina ARC Centre of Excellence in Cognition and its Disorders - Australia Favaloro Univ - Argentina |
| 14 | Sedeno, Lucas | Hombre |
Universidad Favaloro - Argentina
Comision Nacional de Investigacion Cientifica y Tecnologica - Argentina Consejo Nacional de Investigaciones Científicas y Técnicas - Argentina Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) - Argentina Favaloro Univ - Argentina |
| Fuente |
|---|
| Consejo Nacional de Investigaciones Científicas y Técnicas |
| CONICYT/FONDAP |
| Fondo Nacional de Desarrollo Científico y Tecnológico |
| Comisión Nacional de Investigación Científica y Tecnológica |
| PICT |
| Comisión Nacional de Investigación CientÃfica y Tecnológica |
| Fondo Nacional de Desarrollo Científico, Tecnológico y de Innovación Tecnológica |
| Fondo Nacional de Desarrollo CientÃfico y Tecnológico |
| National Health and Medical Research Council |
| Departamento Administrativo de Ciencia, Tecnología e Innovación (COLCIENCIAS) |
| Fondo Nacional de Desarrollo CientÃfico, Tecnológico y de Innovación Tecnológica |
| Inter-American Development Bank (IDB) |
| Consejo Nacional de Investigaciones CientÃficas y Técnicas |
| Inter-American Development Bank |
| Departamento Administrativo de Ciencia, TecnologÃa e Innovación (COLCIENCIAS) |
| NHMRC (National Health and Medical Research Council) |
| CONICYT (National Commission for Scientific and Technological Research)/FONDECYT (National Fund for Scientific and Technological Development) |
| INECO (Institute of Cognitive Neurology) Foundation |
| CONICET (National Scientific and Technical Research Council) |
| CONICYT/FONDAP (National Fund for Scientific and Technological Development) |
| Administrative Department of Science, Technology and Innovation (Colciencias) GRANT |
| Institute of Cognitive Neurology) Foundation |
| INECO |
| Fundacion INECO |
| Agradecimiento |
|---|
| This work was supported by grants from CONICYT (National Commission for Scientific and Technological Research)/FONDECYT (National Fund for Scientific and Technological Development) Regular (1170010); CONICET (National Scientific and Technical Research Council); CONICYT/FONDAP (National Fund for Scientific and Technological Development) 15150012; the INECO (Institute of Cognitive Neurology) Foundation; PICT, Grant/Award Number: 2017-1818 and 2017-1820; by the Inter-American Development Bank (IDB); by the Administrative Department of Science, Technology and Innovation (Colciencias) GRANT: 697-2014, 545-211; and the NHMRC (National Health and Medical Research Council). |
| This work was supported by grants from CONICYT (National Commission for Scientific and Technological Research)/FONDECYT (National Fund for Scientific and Technological Development) Regular (1170010); CONICET (National Scientific and Technical Research Council); CONICYT/FONDAP (National Fund for Scientific and Technological Development) 15150012; the INECO (Institute of Cognitive Neurology) Foundation; PICT, Grant/ Award Number: 2017-1818 and 2017-1820; by the Inter-American Development Bank (IDB); by the Administrative Department of Science, Technology and Innovation (Colciencias) GRANT: 697-2014, 545-211; and the NHMRC (National Health and Medical Research Council). |