This study describes experiences and perceptions on interculturality in Primary Health Care (PHC) from the perspective of health workers and mapuche health users. For this purpose, a qualitative systematization of these experiences was carried out in a PHC Intercultural Health Program at an urban commune in Chile. Data was collected by means of individual and group interviews, respectively, with 19 users and 13 professionals, and then investigated using semantic content analysis. While user perceive mapuche health positively, assimilating it to the concept of interculturality, health workers reported that mapuche health is respected, but not integrated into the routine. As barriers, the participants cited administrative aspects, lack of integration and scientific issues. In conclusion, recognition of indigenous health and greater occupational training on indigenous health and interculturality is necessary.