In this article, we examine the ways in which the notion of interdisciplinarity was understood, implemented and experienced by researchers at a government-funded Chilean climate research centre. Our multi-site ethnography, consisting of interviews, participant observations, and document analysis, was motivated by three key aims. First, to generate an inductive, multi-faceted picture of the lived meaning of "interdisciplina" at the Centre; second, to explore whether and to what extent the "peripheral" features of the research context would exacerbate the challenges associated with practicing interdisciplinarity, and third, to see whether frictions between disciplines at the Centre could be considered productive "dissonances" in Stark's sense of the term. We found that despite the centre efforts to produce a common framework to regulate interdisciplinary research, its researchers nevertheless understood, enacted and experienced it in diverse ways. More specifically, we found that researcher ' s conceptions of interdisciplinarity were coloured by their lived experiences of attempting to practice it, and in particular by the benefits and costs they associated with doing so. This in turn was linked to several variables, including the specific balance between disciplines, the absence or presence of shared, clearly-defined goals, the affirmation of a common research ethic or motivational commitment, and the structural-material conditions of the research in question. We also found that the research conditions characteristic of the Global South do tend to exacerbate the well-documented challenges associated with interdisciplinarity, yet that the adversities associated with precarious conditions were often met by increased resilience and bonding among researchers, who use creative and collaborative strategies to adapt to adversity.