Objective: We analyze the dynamics of the mental well-being of the Chilean population in response to the progress of the vaccination strategy implemented by the government. Study design: This study aims at investigating the possibility of using Google Trends as an instrument for tracking mental well-being of the Chilean population. Methods: We use the volume of searches for keywords in Google Trends (GT) related to Anguish, Anxiety, Depression, and Stress as a proxy for population well-being. Using event study methods, we analyze social attention reactions to news about the vaccination program. We implement a Difference-in-Difference-in -Differences estimation to estimate changes in population welfare by socio-economic status induced by the progress of inoculation. Results: We show that social attention to mental health problems is sensitive to news about the vaccination program. Moreover, and most importantly, we find that mental well-being responds positively to the per-centage of inoculated people. This phenomenon appear to be permanent and affected by socio-economic status, with the wealthier population experiencing greater improvements than the less wealthy. Conclusions: During the COVID-19 vaccination program in Chile, social attention to mental health problems appears to be sensitive to news about the vaccination program. There is also strong evidence of socio-economic status-induced heterogeneity in population responses to program implementation. The above phenomena appears to be permanent and cannot be attributed to either socio-economic segre-gation in access to vaccines or to the highly stratified schedule of the vaccination program. (c) 2023 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.