Colombia is in one of the most active seismic zones onEarth, where the Nazca, Caribbean, and South American plates converge.Approximately 83 % of the national population lives in intermediate tohigh seismic hazard zones, and a significant part of the country's buildinginventory dates from before the nation's first seismic design code (1984).At present, seismic risk scenarios are available for the major cities of the country, but there is still a need to undertake such studies in otherregions. This paper presents a seismic risk scenario for the SabanaCentro province, an intermediate hazard zone located close to thecountry's capital. An exposure model was created combining information fromthe Global Earthquake Model (GEM) Foundation, surveys, and the nationalcensus. Fragility and vulnerability curves were assigned to the buildingtypes of the region. A hazard model was developed for the region and18 earthquake scenarios with a return period of 475 years weresimulated using the OpenQuake (OQ) hazard and risk assessment tool toestimate damage and economic losses. In addition, a social vulnerabilityindex (SVI) based on demographic information was used to assess the directeconomic loss in terms of replacement costs. The results show that 10 % of all buildings considered in the region would experience collapse, and 7 % would suffer severe damage. Losses account for 14 % of the total replacement cost of the buildings and represent 21 % of the annual gross domestic product (GDP) of the region.