The Latin American Giant Observatory (LAGO) is a distributed cosmic ray observatory at a regional scale in Latin America, by deploying a large network of Water Cherenkov detectors (WCD) and other astroparticle detectors in a wide range of latitudes from Antarctica to México, and altitudes from sea level to more than 5500 m a.s.l. Detectors telemetry, atmospherics conditions and flux of secondary particles at the ground are measured with extreme detail at each LAGO site by using our own-designed hardware and firmware (ACQUA). To combine and analyse all these huge amount of data, LAGO developed ANNA, our data analysis framework. Additionally, ARTI, a complete framework of simulations designed to simulate the expected signals at our detectors coming from primary cosmic rays entering the Earth atmosphere, allowing a precise characterization of the sites in realistic atmospheric, geomagnetic and detector conditions. As the measured and synthetic data started to flow, we are facing challenging scenarios given the large amount of data emerging, performed on a diversity of detectors and computing architectures and e-infrastructures. These data need to be transferred, analyzed, catalogued, preserved, and provided for internal and public access and data-mining under an open e-science environment. In this work, we present the implementation of ARTI at the EOSC-Synergy cloud-based services as the first example of LAGO’ frameworks that will follow the FAIR principles for provenance, data-curation and re-using of data. For this we calculate the flux of secondary particles expected in up to 1 week at detector level for all the 26 LAGO, and the 1-year flux of high energy secondaries (pS > 800 GeV/c) expected at the ANDES Underground Laboratory and other sites. Therefore, we show how this development can help not only to LAGO but other data-intensive cosmic rays observatories, muography experiments and underground laboratories.