The objective of the research was to determinate the stressors that most that affect the students who study clinical nursing practices at a Chilean University. The research was carried out through a descriptive, cross-sectional quantitative study. The instrument that was applied was the Kezkak questionnaire, which measures the stress factors of students compared to clinical practices. The sample was 93 students from the nursing career at a Chilean University. The results showed that the most stressful situations in clinical practice are: “doing my job wrong and harming the patient”, “confusing myself with medication”, “the differences between what we learn in class and what we see in practice”.