Background: Cognition and quality of life may be influenced by genetics, environment, age of onset of seizures, duration and severity of the disease, types of seizures, and antiepileptic drugs (AED). Objective: To analyze the relationship between clinical data, cognitive performance, and quality of life in women with epilepsy during childbearing age. Method: This was a cross-sectional, quantitative study at the Center for Neurosciences of the Bahiana School of Medicine and Public Health. Twenty-two women were included. Two instruments for assessing the quality of life and one for Neuropsychological function were used. The data were analyzed with SPSS statistic software. Results: The average age was 27.32 years, single, most unemployed, with impairment in memory, praxis, and executive functions. Those who started seizures later presented higher energy and fewer medication effects, and employed women have better body image and higher self-esteem. Conclusion: Women of childbearing age are at greater risk of being unemployed and without a partner. Associated with cognitive impairments can promote delays in several aspects of quality of life. Clinical conditions such as the onset of the first seizure early also appear to be more vulnerable to the effects of treatment.