Insect consumption or entomophagy is widespread throughout the world. In the Alto Rio Negro-Vaupes border region of the Colombian and Brazilian Amazon region, sedentary and nomadic indigenous peoples include a significant number of insects in their diets. Although this fact has been mentioned in the literature, most of the contents refer merely to intake, leaving aside the symbolic associations of this practice and disregarding the particular conditions for the adaptation of these peoples. This study draws a comparative view of the use and symbology related to insects of two population groups, which hold differences in adaptation terms but live in interaction with each other in the same cultural area.