Root growth and its adaptation are quite important for efficient use of water and nutrients. The present study investigated the effects of alternate partial root-zone irrigation (APRI) coupled with nitrogen application on root growth and nitrogen-use efficiency (NUE) of maize (Zea mays L.). Treatments (conducted at Wuwei City, northwest China) included APRI with controlled irrigation at 45%, 65%, and 80% of field capacity (FC) (W1, W2, and W3, respectively) coupled with nitrogen application rate of 100, 200, and 300 kg N ha(-1) (N1, N2, and N3, respectively). The study found a significant interaction effect of irrigation regimes and nitrogen application rates on maize root growth and NUE. Compared with N2, N3 did not increase the length, surface area, weight, and volume of roots at the filling and maturity stages under W2, while it did under W3, which suggests that increasing nitrogen application rates did not compensate for the adverse effect of drought on root growth. In addition, NUE positively correlated with these root morphological parameters but negatively with the root-to-shoot ratio at the filling and maturity stages. The W2N2 treatment with moderate soil moisture and relatively high soil nitrate-nitrogen promoted total root growth and deeper roots and optimized vertical root distribution, with a low root-to-shoot ratio, resulting in the greatest NUE. These results suggest that moderately controlled irrigation (W2) combined with a reasonable nitrogen rate (N2) improves root growth and optimizes root distribution, resulting in a high NUE in maize under alternate partial root-zone irrigation.