This text makes an ethnographic approach to the relational complexity present in the Amazonian territories, where the care and cure routes detonate a fact that cannot go unnoticed and is the presence of religious institutions that echoes up to the present time and that marks with deep wounds the history and the life courses that are woven there. Marks of a mainly missional legacy of the Catholic Church manifested in Jesuits and Franciscans, which in addition to spiritual disputes, leads to tensions and re-existence between the actors involved in the care and healing processes.