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Going deep into schizophrenia with artificial intelligence
Indexado
WoS WOS:000815955100012
Scopus SCOPUS_ID:85108542860
DOI 10.1016/J.SCHRES.2021.05.018
Año 2022
Tipo artículo de investigación

Citas Totales

Autores Afiliación Chile

Instituciones Chile

% Participación
Internacional

Autores
Afiliación Extranjera

Instituciones
Extranjeras


Abstract



Despite years of research, the mechanisms governing the onset, relapse, symptomatology, and treatment of schizophrenia (SZ) remain elusive. The lack of appropriate analytic tools to deal with the heterogeneity and complexity of SZ may be one of the reasons behind this situation. Deep learning, a subfield of artificial intelligence (AI) inspired by the nervous system, has recently provided an accessible way of modeling and analyzing complex, high-dimensional, nonlinear systems. The unprecedented accuracy of deep learning algorithms in classification and prediction tasks has revolutionized a wide range of scientific fields and is rapidly permeating SZ research. Deep learning has the potential of becoming a valuable aid for clinicians in the prediction, diagnosis, and treatment of SZ, especially in combination with principles from Bayesian statistics. Furthermore, deep learning could become a powerful tool for uncovering the mechanisms underlying SZ thanks to a growing number of techniques designed for improving model interpretability and causal reasoning. The purpose of this article is to introduce SZ researchers to the field of deep learning and review its latest applications in SZ research. In general, existing studies have yielded impressive results in classification and outcome prediction tasks. However, methodological concerns related to the assessment of model performance in several studies, the widespread use of small training datasets, and the little clinical value of some models suggest that some of these results should be taken with caution.

Revista



Revista ISSN
Schizophrenia Research 0920-9964

Métricas Externas



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Disciplinas de Investigación



WOS
Psychiatry
Scopus
Psychiatry And Mental Health
Biological Psychiatry
SciELO
Sin Disciplinas

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Publicaciones WoS (Ediciones: ISSHP, ISTP, AHCI, SSCI, SCI), Scopus, SciELO Chile.

Colaboración Institucional



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Autores - Afiliación



Ord. Autor Género Institución - País
1 Cortes-Briones, Jose A. Hombre VA Connecticut Hlthcare Syst - Estados Unidos
Connecticut Mental Hlth Ctr - Estados Unidos
YALE UNIV - Estados Unidos
Yale School of Medicine - Estados Unidos
VA Connecticut Healthcare System - Estados Unidos
Connecticut Mental Health Center - Estados Unidos
2 Tapia-Rivas, Nicolas I. Hombre Universidad de Chile - Chile
3 D'Souza, Deepak Cyril Hombre VA Connecticut Hlthcare Syst - Estados Unidos
Connecticut Mental Hlth Ctr - Estados Unidos
YALE UNIV - Estados Unidos
Yale School of Medicine - Estados Unidos
VA Connecticut Healthcare System - Estados Unidos
Connecticut Mental Health Center - Estados Unidos
4 ESTEVEZ-VALENCIA, PABLO ANTONIO Hombre Universidad de Chile - Chile

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Financiamiento



Fuente
Fondo Nacional de Desarrollo Científico y Tecnológico
National Institutes of Health
Yale University
Brain and Behavior Research Foundation
Wallace Foundation
Takeda
Roche
Takeda Pharmaceuticals U.S.A.
ANID-Chile
CH TAC
Heffter Research Institute

Muestra la fuente de financiamiento declarada en la publicación.

Agradecimientos



Agradecimiento
JAC reports receiving funding administered through Yale University from the National Institutes of Health, and the Brain and Behavior Research Foundation. DCD reports receiving funding administered through Yale University from the National Institutes of Health, the Brain and Behavior Research Foundation, the Wallace Foundation, CH TAC, LLC, Takeda, Roche, and the Heffter Research Institute. PE reports receiving funding from ANID-Chile.
JAC reports receiving funding administered through Yale University from the National Institutes of Health , and the Brain and Behavior Research Foundation . DCD reports receiving funding administered through Yale University from the National Institutes of Health , the Brain and Behavior Research Foundation , the Wallace Foundation , CH TAC, LLC , Takeda , Roche , and the Heffter Research Institute . PE reports receiving funding from ANID-Chile .
JAC reports receiving funding administered through Yale University from the National Institutes of Health , and the Brain and Behavior Research Foundation . DCD reports receiving funding administered through Yale University from the National Institutes of Health , the Brain and Behavior Research Foundation , the Wallace Foundation , CH TAC, LLC , Takeda , Roche , and the Heffter Research Institute . PE reports receiving funding from ANID-Chile .

Muestra la fuente de financiamiento declarada en la publicación.