The Valdivian temperate rainforest (VTR) is a biome on the South American continent with high endemism that has experienced an intensive land-cover change in recent decades due to the expansion of agriculture, plantations of introduced forests, and urban growth. Today, the biome hosts key parts of the country's agricultural and forestry industries. Previous studies focused on quantifying native forest and plantation cover area and exotic forest plantation area, among others. However, the importance of mountain areas as refuge of native forest in Chile remains unexplored. The aim of this research is to highlight the role of latitude and slope on land cover in the VTR. A new methodological approach was used combining global classified datasets. Our results indicate that high mountain areas are the core location of the remaining primary forests and endemism whereas low mountain areas are dominated by exotic forest plantations. Between 40-48 degrees S (The Los Rios, Los Lagos, and Aysen Regions and high-mountain areas), in general, serve as a natural reservoir where human-induced land-cover change has not occurred on a large scale. Most public and private conservation areas are in high mountain areas, whereas low mountain areas and plain areas lack conservation schemes and are more prone to land cover change towards forestry. Considering geomorphological features in land cover change analysis can reveal interesting new perspectives in this research area.