The reconstruction of glacier fluctuations during the latest Holocene (<1000 years) is necessary for understanding the climate context preceding the warmer conditions of the 20th and 21st centuries. The glacier records in the Andes of central Chile are suitably located to track former latitudinal changes of the Southern Westerly Winds (SSW), which are mostly unknown at this middle latitude region. Here, we present a reconstruction of the glacial fluctuations using Terrestrial Cosmogenic Nuclides (10Be) dating of boulders resting on moraines and other glacial landforms that make up the moraine complex in the forefield of the Universidad Glacier (34 degrees S). This massive and chaotic-looking moraine was built during the latest Holocene ice advances and subsequent decay of the Universidad Glacier to its present position. Geomorphological mapping and 10Be surface exposure ages (n = 20) show that the Universidad Glacier advanced at least twice to nearly the same maximum extent, first by the 13th to 16th centuries and then by the early to the mid-19th century. Since then, eight moraine ridges denote a rather active and gradual ice demise. We interpret the glacier advances as a response to an equatorward shift of the SWW linked to a long-term negative phase of the Southern Annular Mode (SAM), which embraced net humid and cold atmospheric conditions in central Chile between the 13th century and the mid-19th century. Our glacier chronology is comparable to others from Patagonia and New Zealand, altogether exposing the culmination of the latest Holocene glacial maximum by the mid-19th century, before overall ice decay in a global warming world, with accelerated ice loss since the mid-20th century. (c) 2022 Elsevier Ltd. All rights reserved.