Introduction: Assessing the maturity of the midpalatal suture (MPS) is important in orthodontics and dentofacial orthopedics, to decide the type of treatment for palatal expansion, in patients with maxillary compression. An-gelieri et al. in 2013, proposed a method for evaluating the maturation of MPS with cone-beam computed tomo-graphy. No publications were found which analyze articles describing and applying the Angelieri’s method. The purpose of this review is to analyze the Angelieri´s method, describing its uses, advantages and disadvantages. Review: Angelieri’s method classifies MPS maturation into 5 stages (A-E). Its use complements studies with conventional bi-dimensional radiographs, when they indicate the patient is in circumpubertal and post-peak pubertal stages. The identification of the stage of maturation of MPS allows to determine the treatment alternatives-orthopedic or with a surgical approach-according to whether MPS is without ossification or with partial/total ossification, respectively. Some advantages of the Angelieri’s method are being a non-invasive method, and reproducible after adequate training. One of its disadvantages is the lack of a gold standard that proves the imaging morphology of MPS proposed by the authors is not only theoretical. Conclusions: Angelieri’s method is useful to evaluate the maturation of MPS, after calibration. There is no agreement that Angelieri’s method is a predictor of treatment success for palatal expansion. Further research is required on the contribution of this method to its clinical use.