In 1530 the famous Veronese Renaissance doctor Geronimus Fra-castorius wrote the immortal poem “Syphilis sive de morbo gallicus libre tres” (The three books of syphilis or French disease). This work is a beautiful Latin poem of 1300 hexameter lines. The first book describes the causes of the disease and the characteristic clinical pre-sentation. In book two the main treatments are mentioned, especially mercury. Finally, in the third book, it is related how the Spanish sailors found natives of the island of Santo Domingo in America infected with syphilis and how they explained the origin of this devastating disease. The natives recounted how their shepherd ancestor named Syphilus had challenged the god Apollo or Phoebus in time immemorial, thus unleashing his wrath and thus being the first infected. From the myth of the shepherd Syphilus derives the current denomination of the disease that in times of Fracastoro was called the “French disease”, “Gallic disease” or “venereal lues”.