Sustainability, entrepreneurship and tourism, destination and hospitality research have attracted scholars’ attention for their relevance in bringing to fruition a future that links economic well-being with the environmental, cultural, and social sustainability of human beings. This article provides a bibliometric overview of the academic research where these topics intersect. To accomplish this, various bibliometric methods are implemented, which include a performance analysis and graphic mapping of the academic production in this specific topic. This research uses the Web of Science database to identify and classify the most preponderant investigations in the field and considers articles, authors, institutions, countries, and journals. To complete the performance analysis, a series of indicators, such as number of papers and number of citations, are used. Graphic visualization maps are produced using the co-citation and co-occurrence of keywords under the Visualization of Similarities—VOSviewer—software. The results show a growing concern for entrepreneurship in sustainable tourism development research, which is evidenced in the increasing number of studies during the last decade. Some influential research institutions and authors from countries including the USA, New Zealand, and Norway are found to be influential leaders in this topic. Additionally, the results show that journals from the area of hospitality, leisure, sport, and tourism are frontrunners in this subject.