Current advances in wave energy technologies have enabled the development of new integrated measurement platforms powered by the energy of wave motion. Instrumentation is now being deployed for the long-term observation of the coastal ocean, with the objectives of analyzing the performance of wave energy converters (WECs) and studying their interactions with the surrounding environment and marine life. In this work, we present the most relevant findings of the installation and initial operation of the Open Sea Lab (OSL), the first coastal observatory in Latin America powered entirely by a WEC device. We evaluated the preliminary data regarding the combined operation of the system, the generation of energy, and the observations obtained by the continuous monitoring of physical variables at the site. The data showed the seasonal variability of the energy produced by the WEC for a range of wave heights during the period of observation. We also investigated the rapid development of biofouling on mooring lines, junction boxes, and other parts of the system, which is characteristic of the settlement and growth of organisms in this ocean region. These analyses show how this new facility will advance our understanding of the coastal environment in the south Pacific Ocean and foster new interdisciplinary collaborations addressing environmental and technical challenges, thereby contributing to the development of wave energy on the continent.