Over the past several years, there has been a significant increase in the number of Black transgender women murdered in the United States. Black transgender women exist at multiple intersections of oppression and suffer the highest levels of discrimination of all transgender people. This review uses an intersectional approach as a tool to analyze how the intersection of racism, sexism, classism, and cissexism as overlapping oppressions contribute to femicide of black transgender women. The reviews shows that these "isms" operate simultaneously to increase their vulnerability to femicide and exclusion from social justice movements.