The land use change in Comalcalco, Tabasco, Mexico, was modeled on the effect of the growth of anthropogenic activities on natural coverages. A spatial analysis was done using the Land Change Modeler (LCM) and exchange rates were calculated. During 2000-2010, 8,391 ha of hydrophilic vegetation and 1,048 ha of water bodies were lost, due to the accelerated growth of 8,391 ha of agricultural use and 810 ha of urban areas. He noted the loss of 3,050 ha of pasture and the increase of 1,415 ha of mangrove. The Markov Chains and the Cellular Automata projected a scenario (2030) where 544 ha of hydrophilic vegetation, 1,048 ha of water bodies and 3,050 of pastureland were lost, due to the increase of 2,425 ha of agricultural use, 1,415 ha of mangrove and 1.110 of the urban area. Spatial analysis and projection highlight the importance of protecting hydrophilic vegetation, water bodies and increasing mangrove areas through an environmental planning that formally establishes zoning defined as: Protected Natural Area, Conservation, Priority Conservation and Utilization, as indicates the environmental management program.