The problem of the ontological limit of Artificial Intelligence and transhumanism in contrast with the ontology of Homo sapiens is discussed. Beyond the so-called exogenous or endogenous integration (with their respective prototypes, the android and the cyborg), the scenario of a technological singularity seems to materialize in entities that synthesize biology and technology, for example, by means of a download or transbiomorphosis that translates the neural networks of our mind into the memory of a computer. This is a hybridization that warns us about the advent of new species that could leave Homo sapiens behind. If the human/machine synthesis is the limit desired by the transhumanist program, this limit seems to have crossed, in turn, the very ontological limit of the human, on which science, philosophy and religion had so far more or less agreed -each presenting their own cards.