Background: Infectious diseases are important causes of burden of illness and mortality. Aim: To describe the temporal trends of hospital discharges due to infectious in Chile from 2004 to 2014. Methods: Descriptive study. National Hospital Discharge Registry were used. We included all hospital discharges with main diagnosis of infectious diseases including parasitic diseases. Rates were calculated and standardized. The anual percentage change (APC) was estimated by Poisson regression. Results: During a stated period of time in hospitalization of infectious diseases decreased (APC -4%). Women had fewer hospital discharged compared to men. Patients aged between 0 arid 9 years and those who aged 80 years and older showed greater rates than other age groups. Conclusions: Chile has experimented a reduction in hospital discharges due to infectious diseases.