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PPARβ/δ priming enhances the anti-apoptotic and therapeutic properties of mesenchymal stromal cells in myocardial ischemia–reperfusion injury
| Indexado |
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| DOI | 10.1186/S13287-022-02840-0 | ||||
| Año | 2022 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
Conclusion: Altogether these results revealed that PPAR beta/delta-primed MSC exhibit an increased resistance to oxidative stress and enhanced anti-apoptotic properties on cardiac cells in vitro. PPAR beta/delta-priming appears as an innovative strategy to enhance the cardioprotective effects of MSC and to decrease the therapeutic injected doses. These results could be of major interest to improve MSC efficacy for the cardioprotection of injured myocardium in AMI patients.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Sarre, Charlotte | Mujer |
Univ Montpellier - Francia
Université de Montpellier - Francia Cellules Souches, Plasticité Cellulaire, Régénération Tissulaire et Immunothérapie des Maladies Inflammatoires - Francia |
| 2 | CONTRERAS-LOPEZ, RAFAEL ALEXANDER | Hombre |
Univ Montpellier - Francia
Université de Montpellier - Francia Cellules Souches, Plasticité Cellulaire, Régénération Tissulaire et Immunothérapie des Maladies Inflammatoires - Francia |
| 3 | Nernpermpisooth, Nitirut | - |
Naresuan Univ - Tailandia
Naresuan University - Tailandia |
| 4 | Barrere, Christian | Hombre |
Univ Montpellier - Francia
Université de Montpellier - Francia |
| 5 | Bahraoui, Sarah | Mujer |
Univ Montpellier - Francia
Université de Montpellier - Francia Cellules Souches, Plasticité Cellulaire, Régénération Tissulaire et Immunothérapie des Maladies Inflammatoires - Francia |
| 6 | TERRAZA-AGUIRRE, CLAUDIA FERNANDA | Mujer |
Univ Montpellier - Francia
Université de Montpellier - Francia Cellules Souches, Plasticité Cellulaire, Régénération Tissulaire et Immunothérapie des Maladies Inflammatoires - Francia |
| 7 | Tejedor, Gautier | Hombre |
Univ Montpellier - Francia
Université de Montpellier - Francia Cellules Souches, Plasticité Cellulaire, Régénération Tissulaire et Immunothérapie des Maladies Inflammatoires - Francia |
| 8 | Vincent, Anne | Mujer |
Univ Montpellier - Francia
Université de Montpellier - Francia |
| 9 | LUZ-CRAWFORD, PATRICIA ALEJANDRA | Mujer |
Universidad de Los Andes, Chile - Chile
Ctr Intervent Med Precis & Adv Cellular Therapy - Chile IMPACT - Chile |
| 10 | Kongpol, Kantapich | - |
Univ Montpellier - Francia
Naresuan Univ - Tailandia Université de Montpellier - Francia Naresuan University - Tailandia |
| 11 | Kumphune, Sarawut | - |
Walailak Univ - Tailandia
Walailak University - Tailandia |
| 12 | Piot, Christophe | Hombre |
Univ Montpellier - Francia
Clin Millenaire - Francia Université de Montpellier - Francia Clinique du Millénaire - Francia |
| 13 | Nargeot, Joel | Hombre |
Univ Montpellier - Francia
Université de Montpellier - Francia |
| 14 | Jorgensen, Christian | Hombre |
Univ Montpellier - Francia
CHU Montpellier - Francia Université de Montpellier - Francia Centre Hospitalier Universitaire de Montpellier - Francia Cellules Souches, Plasticité Cellulaire, Régénération Tissulaire et Immunothérapie des Maladies Inflammatoires - Francia |
| 15 | Djouad, Farida | Mujer |
Univ Montpellier - Francia
Université de Montpellier - Francia Cellules Souches, Plasticité Cellulaire, Régénération Tissulaire et Immunothérapie des Maladies Inflammatoires - Francia |
| 16 | Barrere-Lemaire, Stephanie | Mujer |
Univ Montpellier - Francia
Université de Montpellier - Francia |
| Fuente |
|---|
| CNRS |
| Naresuan University |
| INSERM |
| Agence Nationale de la Recherche |
| Centre National de la Recherche Scientifique |
| University of Montpellier |
| Université de Montpellier |
| Institut National de la Santé et de la Recherche Médicale |
| Fondation pour la Recherche Medicale |
| Agence Nationale de Recherche |
| Fonds Marion et Elisabeth Brancher |
| PHC program of Campus France |
| ANR-18-CE18-0010 |
| LabEx ICST ANR |
| SBL |
| PPAR-OA ANR |
| Carlota Fernandez Rico |
| Agradecimiento |
|---|
| This work was supported by Inserm, and the University of Montpellier (FD, SBL, CJ), by CNRS (SBL) as well as by Naresuan University (NN, SK). We also thank the "Fonds Marion et Elisabeth Brancher" for financial support of this project (CS PhD fellowship), la "Fondation pour la Recherche Medicale" (RCL, Postdoctoral fellow in France, no. SPF202005011936), the PHC program of Campus France (project number no. 44928QF; SK and SBL) as well the "Agence Nationale de Recherche" grant for the LabEx ICST ANR grant [ANR-11-LABX-0015; SBL, JN, AV, CB, CP] and PPAR-OA ANR grant [ANR-18-CE18-0010; FD, RCL, CJ]. |
| The authors wish to thank Laura Gallot for her technical assistance for ex vivo experiments and Carlota Fernandez Rico for building figures from Western-blots. The authors are grateful to Biocampus facilities and in particular, Steeve Thirard, Elodie Belan and Karim Mesbah for animal care (iExplore/RAM), Julio Mateos-Langerak and Chamrouen Sar for assistance with microscopy (MRI) as well as Nelly Pirot for histological preparations (RHEM). |
| The authors wish to thank Laura Gallot for her technical assistance for ex vivo experiments and Carlota Fernandez Rico for building figures from Western-blots. The authors are grateful to Biocampus facilities and in particular, Steeve Thirard, Elodie Belan and Karim Mesbah for animal care (iExplore/RAM), Julio Mateos-Langerak and Chamrouen Sar for assistance with microscopy (MRI) as well as Nelly Pirot for histological preparations (RHEM). |
