This issue aims to highlight the barriers that LGBT+ children and young people in the region must overcome, both in and out of school, in order to exercise their right to education. The different articles in this special issue help to critically analyze the experiences of school inclusion of this group in different countries, highlighting the successes and failures of educational policies. In this introduction to the special issue, we will briefly review the theoretical aspects of the right to education and social justice in order to present some ideas and concepts for the debate on inclusion in education. Then, we will present some advances and debts of school inclusion of LGTB+ youth in the region, and the presence of LGTB+ inclusion policies in education agendas. Finally, the articles included in this special issue are presented in order to provide a cross-cutting look at the different topics and countries that are part of this publication.