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Rationale and design of the PeriOperative ISchemic Evaluation-3 (POISE-3): a randomized controlled trial evaluating tranexamic acid and a strategy to minimize hypotension in noncardiac surgery
| Indexado |
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| DOI | 10.1186/S13063-021-05992-1 | ||||
| Año | 2022 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
Discussion: Bleeding and hypotension in noncardiac surgery are common and have a substantial impact on patient prognosis. The POISE-3 trial will evaluate two interventions to determine their impact on bleeding, cardiovascular complications, and mortality.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Marcucci, Maura | Mujer |
MCMASTER UNIV - Canadá
Populat Hlth Res Inst - Canadá McMaster University - Canadá Population Health Research Institute, Ontario - Canadá |
| 2 | Painter, Thomas | Hombre |
Univ Adelaide - Australia
Royal Adelaide Hosp - Australia The University of Adelaide - Australia Royal Adelaide Hospital - Australia |
| 3 | Conen, David | Hombre |
MCMASTER UNIV - Canadá
Populat Hlth Res Inst - Canadá McMaster University - Canadá Population Health Research Institute, Ontario - Canadá |
| 4 | Leslie, K. | Mujer |
Royal Melbourne Hosp - Australia
Univ Melbourne - Australia Royal Melbourne Hospital - Australia Melbourne Medical School - Australia |
| 5 | Lomivorotov, Vladimir | Hombre |
E Meshalkin Natl Med Res Ctr - Rusia
Novosibirsk State Univ - Rusia E.N. Meshalkin National Medical Research Center - Rusia Novosibirsk State University - Rusia |
| 6 | Sessler, Daniel | Hombre |
CLEVELAND CLIN - Estados Unidos
Cleveland Clinic Foundation - Estados Unidos |
| 7 | Chan, Matthew T. V. | Hombre |
Chinese Univ Hong Kong - China
Chinese University of Hong Kong - Hong Kong |
| 8 | Borges, Flavia K. | Mujer |
MCMASTER UNIV - Canadá
Populat Hlth Res Inst - Canadá McMaster University - Canadá Population Health Research Institute, Ontario - Canadá |
| 9 | Martinez-Zapata, Maria José | Mujer |
Institut dInvestigació Biomèdica Sant Pau (IIB Sant Pau) - España
CIBER Epidemiol & Salud Publ CIBERESP - España Institut de Recerca Sant Pau (IR SANT PAU) - España |
| 9 | Zapata, Maria J. Martinez | Mujer |
CIBER Epidemiol & Salud Publ CIBERESP - España
Institut dInvestigació Biomèdica Sant Pau (IIB Sant Pau) - España Institut de Recerca Sant Pau (IR SANT PAU) - España |
| 10 | Guyatt, Gordon H. | Hombre |
Univ Malaya - Malasia
Jagiellonian Univ Med Coll - Polonia MCMASTER UNIV - Canadá Universiti Malaya - Malasia Jagiellonian University Medical College - Polonia McMaster University - Canadá |
| 11 | Xavier, Denis | Hombre |
St Johns Med Coll - India
St. John's Medical College - India |
| 12 | Ofori, Sandra | Mujer |
MCMASTER UNIV - Canadá
Populat Hlth Res Inst - Canadá McMaster University - Canadá Population Health Research Institute, Ontario - Canadá |
| 13 | Landoni, Giovanni | Hombre |
IRCCS San Raffaele Sci Inst - Italia
Univ Vita Salute San Raffaele - Italia IRCCS Ospedale San Raffaele - Italia Facoltà di Medicina e Chirurgia - Italia Università Vita-Salute San Raffaele - Italia |
| 14 | Efremov, Sergey | Hombre |
St Petersburg State Univ Hosp - Rusia
Saint-Petersburg State University Hospital - Rusia |
| 15 | Kleinlugtenbelt, Ydo | - |
Deventer Ziekenhuis - Países Bajos
Deventer Hospitals - Países Bajos |
| 16 | Guyatt, Gordon H. | Hombre |
Univ Malaya - Malasia
Jagiellonian Univ Med Coll - Polonia MCMASTER UNIV - Canadá Universiti Malaya - Malasia Jagiellonian University Medical College - Polonia McMaster University - Canadá |
| 17 | Schmartz, Denis | Hombre |
Univ Libre Bruxelles - Bélgica
Université libre de Bruxelles - Bélgica |
| 18 | Garg, Amit X. | Hombre |
Populat Hlth Res Inst - Canadá
Western Univ - Canadá Population Health Research Institute, Ontario - Canadá Western University - Canadá |
| 19 | Short, Timothy G. | Hombre |
Auckland City Hosp - Nueva Zelanda
UNIV AUCKLAND - Nueva Zelanda Auckland City Hospital - Nueva Zelanda The University of Auckland - Nueva Zelanda |
| 20 | Wittmann, Maria | Mujer |
Universidad Hosp - Alemania
Universitätsklinikum Bonn - Alemania |
| 21 | Meyhoff, Christian S. | Hombre |
Univ Copenhagen - Dinamarca
Københavns Universitet - Dinamarca |
| 22 | Amir, Mohammed | Hombre |
Shifa Int Hosp STMU - Pakistán
Shifa International Hospital - Pakistán |
| 23 | Torres, David | Hombre |
Clínica Santa María - Chile
Universidad de Los Andes, Chile - Chile |
| 24 | Patel, Ameen | Hombre |
MCMASTER UNIV - Canadá
McMaster University - Canadá |
| 25 | Duceppe, E. | Mujer |
Populat Hlth Res Inst - Canadá
UNIV MONTREAL - Canadá Population Health Research Institute, Ontario - Canadá University of Montreal - Canadá |
| 26 | Ruetzler, K. | - |
CLEVELAND CLIN - Estados Unidos
Cleveland Clinic Foundation - Estados Unidos |
| 27 | Parlow, Joel L. | Hombre |
Kingston Gen Hosp - Canadá
Queens Univ - Canadá Kingston General Hospital, Ontario - Canadá |
| 28 | Tandon, Vikas | Hombre |
MCMASTER UNIV - Canadá
McMaster University - Canadá |
| 29 | Wang, Michael K. | Hombre |
MCMASTER UNIV - Canadá
Populat Hlth Res Inst - Canadá McMaster University - Canadá Population Health Research Institute, Ontario - Canadá |
| 30 | Fleischmann, Edith | Mujer |
Med Univ Vienna - Austria
Medizinische Universitat Wien - Austria |
| 31 | Anne-Polanczyk, Carisi | - |
Univ Fed Rio Grande do Sul - Brasil
Hosp Clin Porto Alegre - Brasil Universidade Federal do Rio Grande do Sul - Brasil Hospital de Clínicas de Porto Alegre - Brasil |
| 32 | Jayaram, Raja | Hombre |
UNIV OXFORD - Reino Unido
University of Oxford Medical Sciences Division - Reino Unido |
| 33 | Astrakov, Sergey | Hombre |
City Hosp 25 - Rusia
Novosibirsk State Univ - Rusia City hospital No. 25 - Rusia Novosibirsk State University - Rusia City Clinical Hospital № 25 - Rusia |
| 34 | Rao, M. | - |
St Johns Med Coll - India
St. John's Medical College - India St. John's National Academy Of Health Sciences India - India |
| 35 | Vanhelder, Tomas | Hombre |
MCMASTER UNIV - Canadá
McMaster University - Canadá |
| 36 | Wu, William K. K. | Hombre |
Chinese Univ Hong Kong - China
Chinese University of Hong Kong - Hong Kong |
| 37 | Cheong, Chao Chia | - |
Univ Malaya - Malasia
Universiti Malaya - Malasia |
| 38 | Ayad, Sabry | - |
Case Western Reserve Univ - Estados Unidos
Case Western Reserve University - Estados Unidos |
| 39 | Abubakirov, Marat | Hombre |
Meshalkin Natl Med Res Ctr - Rusia
E.N. Meshalkin National Medical Research Center - Rusia |
| 40 | Kirov, Mikhail | Hombre |
Northern State Med Univ - Rusia
Northern State Medical University - Rusia |
| 41 | Bhatt, Keyur | - |
SIDS Hosp & Res Ctr - India
SIDS Hospital and Research Centre - India SIDS Hospital - India |
| 42 | de Nadal, Miriam | Mujer |
Hosp Univ Vall dHebron - España
Hospital Universitari Vall d'Hebron - España |
| 43 | Likhvantsev, Valery V. | Hombre |
V Negovskiy Reanimatol Res Inst - Rusia
M Vladimirskiy Moscow Reg Clin & Res Inst - Rusia V. Negovskiy Reanimatology Research Institute - Rusia Moscow Regional Research and Clinical Institute - Rusia Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology - Rusia |
| 44 | Iglesisas, Pilar Paniagua | Mujer |
Santa Creu & St Pau Univ Hosp - España
Hospital de La Santa Creu I Sant Pau - España |
| 45 | Aguado, Hector J. | Hombre |
Hospital Clínico Universitario de Valladolid - España
Hosp Clin Univ - España |
| 46 | McGillion, Michael | Hombre |
Populat Hlth Res Inst - Canadá
MCMASTER UNIV - Canadá Population Health Research Institute, Ontario - Canadá McMaster University, Faculty of Health Sciences - Canadá McMaster University - Canadá |
| 47 | Lamy, Andre | Hombre |
Populat Hlth Res Inst - Canadá
MCMASTER UNIV - Canadá Population Health Research Institute, Ontario - Canadá McMaster University - Canadá |
| 48 | Whitlock, R. | Hombre |
Populat Hlth Res Inst - Canadá
MCMASTER UNIV - Canadá Population Health Research Institute, Ontario - Canadá McMaster University - Canadá |
| 49 | Roshanov, Pavel | Hombre |
London Hlth Sci Ctr - Canadá
London Health Sciences Centre - Canadá |
| 50 | Stillo, David | Hombre |
Populat Hlth Res Inst - Canadá
Population Health Research Institute, Ontario - Canadá |
| 51 | Copland, Ingrid | Mujer |
Populat Hlth Res Inst - Canadá
Population Health Research Institute, Ontario - Canadá |
| 52 | Vincent, Jessica | Mujer |
Populat Hlth Res Inst - Canadá
Population Health Research Institute, Ontario - Canadá |
| 53 | Balasubramanian, Kumar | Hombre |
Populat Hlth Res Inst - Canadá
Population Health Research Institute, Ontario - Canadá |
| 54 | Bangdiwala, Shrikant | - |
MCMASTER UNIV - Canadá
Populat Hlth Res Inst - Canadá McMaster University - Canadá Population Health Research Institute, Ontario - Canadá |
| 55 | Biccard, B. M. | Hombre |
Groote Schuur Hosp - República de Sudáfrica
UNIV CAPE TOWN - República de Sudáfrica University of Cape Town - República de Sudáfrica |
| 56 | Kurz, Andrea | Mujer |
CLEVELAND CLIN - Estados Unidos
Med Univ Graz - Austria Cleveland Clinic Foundation - Estados Unidos Medizinische Universität Graz - Austria Medizinische Universitat Wien - Austria |
| 57 | Aguado, Hector J. | Hombre |
Hosp Clin Univ - España
Hospital Clínico Universitario de Valladolid - España |
| 57 | Srinathan, Sadeesh | - |
Univ Manitoba - Canadá
University of Manitoba - Canadá |
| 58 | Petit, Shirley | Mujer |
Populat Hlth Res Inst - Canadá
Population Health Research Institute, Ontario - Canadá |
| 59 | Eikelboom, John | Hombre |
MCMASTER UNIV - Canadá
Populat Hlth Res Inst - Canadá McMaster University - Canadá Population Health Research Institute, Ontario - Canadá |
| 60 | Richards, Toby | Hombre |
Univ Western Australia - Australia
The Faculty of Health and Medical Sciences - Australia |
| 61 | Gross, P. L. | Hombre |
MCMASTER UNIV - Canadá
McMaster University - Canadá |
| 62 | Alfonsi, P. | Hombre |
GH Paris St Joseph - Francia
GH Paris Saint-Joseph - Francia |
| 63 | Guyatt, Gordon H. | Hombre |
Univ Malaya - Malasia
Jagiellonian Univ Med Coll - Polonia MCMASTER UNIV - Canadá Universiti Malaya - Malasia Jagiellonian University Medical College - Polonia McMaster University - Canadá |
| 64 | Belley-Cote, Emilie P. | Mujer |
MCMASTER UNIV - Canadá
Populat Hlth Res Inst - Canadá McMaster University - Canadá Population Health Research Institute, Ontario - Canadá |
| 65 | Spence, Jessica | Mujer |
MCMASTER UNIV - Canadá
Populat Hlth Res Inst - Canadá McMaster University - Canadá Population Health Research Institute, Ontario - Canadá |
| 66 | McIntyre, William | Hombre |
MCMASTER UNIV - Canadá
Populat Hlth Res Inst - Canadá McMaster University - Canadá Population Health Research Institute, Ontario - Canadá |
| 67 | Yusuf, Salim | Hombre |
MCMASTER UNIV - Canadá
Populat Hlth Res Inst - Canadá McMaster University - Canadá Population Health Research Institute, Ontario - Canadá |
| 68 | Devereaux, P. J. | Hombre |
MCMASTER UNIV - Canadá
Populat Hlth Res Inst - Canadá McMaster University - Canadá Population Health Research Institute, Ontario - Canadá |
| Fuente |
|---|
| Instituto de Salud Carlos III |
| Canadian Institutes of Health Research |
| National Health and Medical Research Council |
| Research Grants Council, University Grants Committee |
| Abbott Laboratories |
| Bayer |
| Boehringer Ingelheim |
| National Institute for Health Research |
| Roche |
| Roche Diagnostics |
| Fonds de Recherche du Québec - Santé |
| MRFF |
| Canadian Institutes of Health Research (CIHR) Foundation, Canada |
| General Research Fund, Research Grant Council, Hong Kong SAR, China |
| National Health and Medical Research Council, Funding Schemes, NHMRC, Australia |
| McMaster University Department of Medicine |
| Western Australia FHRF |
| Physicians' Services Incorporated |
| Funding Schemes |
| NIHR HTA |
| Canadian HIV Trials Network, Canadian Institutes of Health Research |
| Agradecimiento |
|---|
| The study is supported by the following grants: Canadian Institutes of Health Research (CIHR) Foundation Grant awarded to PJD (FDN-143302), Canada; General Research Fund 14104419, Research Grant Council, Hong Kong SAR, China; and National Health and Medical Research Council, Funding Schemes, NHMRC Project Grant 1162362, Australia. MM holds a McMaster University Department of Medicine Career Research Award and a Physicians' Services Incorporated (PSI) Foundation Mid-Career Clinical Research Award to support her research work in perioperative medicine. FKB holds a McMaster University Department of Medicine Career Research Award to support her research work in perioperative medicine. |
| The study is supported by the following grants: Canadian Institutes of Health Research (CIHR) Foundation Grant awarded to PJD (FDN-143302), Canada; General Research Fund 14104419, Research Grant Council, Hong Kong SAR, China; and National Health and Medical Research Council, Funding Schemes, NHMRC Project Grant 1162362, Australia. MM holds a McMaster University Department of Medicine Career Research Award and a Physicians' Services Incorporated (PSI) Foundation Mid-Career Clinical Research Award to support her research work in perioperative medicine. FKB holds a McMaster University Department of Medicine Career Research Award to support her research work in perioperative medicine. |
