Sarcoptic mange is considered an emerging disease-causing countless epizootics and significantly affecting wild mammals worldwide. The vicuna (Vicugna vicugna) is a medium-sized South American wild camelid inhabiting Andean ecosystems, where several populations are live-sheared by Andean peasant communities as a way of providing an economic income to the people while promoting vicuna conservation. Institutions and scientists have shown concern for the impact and extent of sarcoptic mange in several vicuna populations across their range, as well as the lack of consistent knowledge about this disease in the species. Here, we perform a review about sarcoptic mange distribution throughout the vicuna's native range, evidence of effects of age and sex, the modes of transmission and the veterinary treatments employed. The review retrieved a few scientific papers, but found several reports and academic studies mostly considered as 'grey literature'. Mange was recorded across the entire native vicuna range (Argentina, Bolivia, Chile and Peru). Mange prevalence varied across vicuna studies (up to 60% prevalence in some populations) and severely affected a number of populations, being an important source of mortality. Mange was reported as more frequent in adults than in offspring. The modes of mange transmission remain unclear, although direct transmission between infected and healthy animals seems to be the most likely, including the transmission between domestic camelids and vicunas. Regarding the treatments employed, ivermectin was the most frequently used. We further identified several gaps in knowledge and point to future research lines, which seek to promote both species conservation and the maintenance of live-shearing vicunas under sustainable approaches in low-income Andean peasant communities.