The article studies the construction process of the Argentine-Uruguayan Hortus Conclusus sanctuary, inaugurated in Palestine in 1902. It focuses on the project's diffusion and the construction of solidarity networks between Latin America, Rome and Palestine articulated by the Archbishop of Montevideo Mariano Soler. The central argument is that the case studied exhibits some particularities of the "global turn" of the Catholic Church in the Rio de la Plata, which rather than being a passive recipient of congregations, images and devotions received from European "centers" of Catholic renovation, functioned as a dynamic space of appropriation and even universalization for many of these forms and images. This can be perceived by reconstructing the life of transnational agents and projects that linked different places in the world, amplifying the global consciousness of Catholicism at the local, national, and continental levels. Also, the article exemplifies how a Marian devotion was able to function as a symbolic space in service of political identities, and as a vehicle for (trans)national movements.