Office buildings are usually characterized by low thermal inertia, which could cause underperformance in terms of energy consumption. Moreover, the use of large, glazed façades in office buildings can cause thermal and visual discomfort due to high solar heat gains and excessive daylight transmitted into the office space. Phase Change Materials (PCMs) integrated into glazing have arisen as an innovative strategy to increase thermal inertia and improve office buildings’ energy performance and indoor comfort at a low cost. This paper aims to analyze the impact of PCM glazing on buildings’ energy performance and occupants’ thermal and visual comfort. The analysis is performed through a one-year real-scale experiment in two offices in Santiago, Chile, with an east-oriented façade and a window-to-wall ratio (WWR) of 56%. The results are analyzed on two timescales: seasonally and daily. Representative days in each season were selected to carry out the analysis. Regarding the energy consumption of the HVAC system, PCM glazing reduces energy consumption during summer and mid-seasons and significantly reduces the peak loads in summer. A meaningful improvement in thermal comfort is achieved due to the control of the mean radiant temperature for the whole year. Considering visual comfort, there is an improvement in the luminance distribution in winter and mid-season cold conditions.