Bofedales are azonal peat-forming wetlands located in the tropical and subtropical Andes at high altitudes (approximately 3200–5000 m). Motivated by their socio-ecological importance, unique landscape qualities, and increasing vulnerability, scholars have developed a rich research agenda to better understand this ecosystem. We conducted an analysis of the various frameworks used to study bofedales through a systematic review of 119 key academic publications. We observed a range of bofedal naming terminologies, definitions, and descriptions of key threats that sometimes aligned with disciplinary, geographic, or linguistic distinctions between studies. Notably, though the majority of papers employed natural science methods, the social science and multidisciplinary studies were more likely to discuss the role of local communities in helping manage these ecosystems, though many researchers also highlighted the need for further study of these dynamics. This analysis, therefore, demonstrates the need to develop research modalities that are rooted in local contexts and which employ both quantitative and qualitative methods to investigate and elucidate the complex human-environment dynamics that characterize these ecosystems. By documenting, we aim to support more robust research collaborations and to inform the development of research and conservation agendas that effectively support these landscapes and the myriad socio-ecological services they provide.