Significant action is needed across the Chilean housing sector to reduce energy consumption and meet climate change mitigation goals. In this study, the performance of a typical house, an optimised house and a Passivhaus in various climates is evaluated and compared, considering eight distinct climatic zones of Chile. For the thermal optimisation of the house, an OpenBIM workflow between REVIT-CYPETHERM and EnergyPlus with JEPlus were interfaced to analyse over a thousand possible combinations of energy optimisation measures for each climate zone. Additionally, a Life Cycle Assessment is used to compare the cases studied. The results show that in the manufacturing stage, building a Passivhaus would have greater environmental impacts than a traditional house. Additionally, it is shown that in warm climatic zones, a thermally optimised house can have an energy performance equivalent to housing constructed to Passivhaus standards but with less environmental impacts in all its phases of the life cycle.