Muestra métricas de impacto externas asociadas a la publicación. Para mayor detalle:
| Indexado |
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| DOI | 10.3390/BRAINSCI11070887 | ||||
| Año | 2021 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Impairments of action semantics (a cognitive domain that critically engages motor brain networks) are pervasive in early Parkinson's disease (PD). However, no study has examined whether action semantic skills in persons with this disease can be influenced by non-invasive neuromodulation. Here, we recruited 22 PD patients and performed a five-day randomized, blinded, sham-controlled study to assess whether anodal transcranial direct current stimulation (atDCS) over the primary motor cortex, combined with cognitive training, can boost action-concept processing. On day 1, participants completed a picture-word association (PWA) task involving action-verb and object-noun conditions. They were then randomly assigned to either an atDCS (n = 11, 2 mA for 20 m) or a sham tDCS (n = 11, 2 mA for 30 s) group and performed an online PWA practice over three days. On day 5, they repeated the initial protocol. Relative to sham tDCS, the atDCS group exhibited faster reaction times for action (as opposed to object) concepts in the post-stimulation test. This result was exclusive to the atDCS group and held irrespective of the subjects' cognitive, executive, and motor skills, further attesting to its specificity. Our findings suggest that action-concept deficits in PD are distinctively grounded in motor networks and might be countered by direct neuromodulation of such circuits. Moreover, they provide new evidence for neurosemantic models and inform a thriving agenda in the embodied cognition framework.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | SUAREZ-GARCIA, DIANA MARIA ALEJANDRA | Mujer |
UNIV VALLE - Colombia
Universidad del Valle, Cali - Colombia |
| 2 | Birba, Agustina | Mujer |
Univ San Andres - Argentina
Natl Sci & Tech Res Council CONICET - Argentina Universidad de San Andrés - Argentina Consejo Nacional de Investigaciones Científicas y Técnicas - Argentina |
| 3 | Zimerman, Maximo | - |
Univ San Andres - Argentina
Universidad de San Andrés - Argentina |
| 4 | Diazgranados, Jesus A. | Hombre |
Ctr Med Atenc Neurol Neurologos Occidente - Colombia
Centro Médico de Atención Neurológica ‘Neurólogos de Occidente’ - Colombia |
| 5 | Lopes da Cunha, Pamela | Mujer |
Univ San Andres - Argentina
Agencia Nacl Promoc Cient & Tecnol ANPCyT - Argentina Universidad de San Andrés - Argentina Agencia Nacional de Promoción Científica y Tecnológica, Buenos Aires - Argentina |
| 5 | da Cunha, Pamela Lopes | Mujer |
Universidad de San Andrés - Argentina
Agencia Nacional de Promoción Científica y Tecnológica, Buenos Aires - Argentina Univ San Andres - Argentina Agencia Nacl Promoc Cient & Tecnol ANPCyT - Argentina |
| 6 | LEGAZ, AGUSTINA | Mujer |
Univ San Andres - Argentina
Natl Sci & Tech Res Council CONICET - Argentina Univ Calif San Francisco UCSF - Estados Unidos Trinity Coll Dublin TCD - Irlanda Universidad Adolfo Ibáñez - Chile Universidad de San Andrés - Argentina Consejo Nacional de Investigaciones Científicas y Técnicas - Argentina University of California, San Francisco - Estados Unidos Trinity College Dublin - Irlanda |
| 7 | Grisales-Cardenas, Johan S. | Hombre |
UNIV VALLE - Colombia
Universidad del Valle, Cali - Colombia |
| 8 | CARDONA-LONDONO, JUAN FELIPE | Hombre |
UNIV VALLE - Colombia
Universidad del Valle, Cali - Colombia |
| 9 | Garcia, Adolfo M. | Hombre |
Univ San Andres - Argentina
Natl Sci & Tech Res Council CONICET - Argentina Univ Calif San Francisco UCSF - Estados Unidos Trinity Coll Dublin TCD - Irlanda Natl Univ Cuyo UNCuyo - Argentina Universidad de Santiago de Chile - Chile Universidad de San Andrés - Argentina Consejo Nacional de Investigaciones Científicas y Técnicas - Argentina University of California, San Francisco - Estados Unidos Trinity College Dublin - Irlanda Universidad Nacional de Cuyo - Argentina |
| Fuente |
|---|
| Consejo Nacional de Investigaciones Científicas y Técnicas |
| CONICET |
| FONCyT-PICT |
| FONDAP |
| Fondo Nacional de Desarrollo Científico y Tecnológico |
| National Institutes of Health |
| Universidad del Valle |
| Alzheimer's Association |
| Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias |
| National Institute on Aging |
| Programa Interdisciplinario de Investigacion Experimental en Comunicacion y Cognicion (PIIECC), Facultad de Humanidades, USACH |
| Alzheimer Association |
| Global Brain Health Institute |
| ANID |
| Facultad de Humanidades |
| Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat) - National Institutes of Aging of the National Institutes of Health |
| Rainwater Foundation |
| MinCiencias |
| ANID/FONDECYT Regular |
| Agradecimiento |
|---|
| This work was partially supported by grants from MINCIENCIAS (1106-744-55314); Universidad del Valle (CI 5276, 5292); CONICET; ANID/FONDECYT Regular (1210176, 1210195); FONCYT-PICT (2017-1818, 2017-1820); FONDAP (15150012); Programa Interdisciplinario de Investigacion Experimental en Comunicacion y Cognicion (PIIECC), Facultad de Humanidades, USACH; Alzheimer Association GBHI ALZ UK-20-639295; and the Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat), funded by the National Institutes of Aging of the National Institutes of Health (R01AG057234), an Alzheimer's Association grant (SG-20-725707-ReDLat), the Rainwater Foundation, and the Global Brain Health Institute. The content is solely the responsibility of the authors and does not represent the official views of these stakeholders. |
| Funding: This work was partially supported by grants from MINCIENCIAS (1106-744-55314); Universidad del Valle (CI 5276, 5292); CONICET; ANID/FONDECYT Regular (1210176, 1210195); FONCYT-PICT (2017-1818, 2017-1820); FONDAP (15150012); Programa Interdisciplinario de Investi-gación Experimental en Comunicación y Cognición (PIIECC), Facultad de Humanidades, USACH; Alzheimer Association GBHI ALZ UK-20-639295; and the Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat), funded by the National Institutes of Aging of the National Institutes of Health (R01AG057234), an Alzheimer’s Association grant (SG-20-725707- ReDLat), the Rainwater Foundation, and the Global Brain Health Institute. The content is solely the responsibility of the authors and does not represent the official views of these stakeholders. |