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| Indexado |
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| DOI | 10.1177/09622802211013830 | ||||
| Año | 2021 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
A key hypothesis in epidemiological studies is that time to disease exposure provides relevant information to be considered in statistical models. However, the initiation time of a particular condition is usually unknown. Therefore, we developed a multiple imputation methodology for the age at onset of a particular condition, which is supported by incidence data from different sources of information. We introduced and illustrated such a methodology using simulated data in order to examine the performance of our proposal. Then, we analyzed the association of gallstones and fatty liver disease in the Maule Cohort, a Chilean study of chronic diseases, using participants' risk factors and six sources of information for the imputation of the age-occurrence of gallstones. Simulated studies showed that an increase in the proportion of imputed data does not affect the quality of the estimated coefficients associated with fully observed variables, while the imputed variable slowly reduces its effect. For the Chilean study, the categorized exposure time to gallstones is a significant variable, in which participants who had short and long exposure have, respectively, 26.2% and 29.1% higher chance of getting a fatty liver disease than non-exposed ones. In conclusion, our multiple imputation approach proved to be quite robust both in the linear/logistic regression simulation studies and in the real application, showing the great potential of this methodology.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Alvares, Danilo | Hombre |
Pontificia Universidad Católica de Chile - Chile
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| 2 | Paredes, Fabio | Hombre |
Adv Ctr Chron Dis ACCDiS - Chile
Pontificia Universidad Católica de Chile - Chile Advanced Center for Chronic Diseases (ACCDiS) - Chile |
| 3 | Vargas, Claudio | Hombre |
Adv Ctr Chron Dis ACCDiS - Chile
Universidad de Santiago de Chile - Chile Advanced Center for Chronic Diseases (ACCDiS) - Chile |
| 4 | Ferreccio, Catterina | - |
Adv Ctr Chron Dis ACCDiS - Chile
Pontificia Universidad Católica de Chile - Chile Advanced Center for Chronic Diseases (ACCDiS) - Chile |
| Fuente |
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| Fondo Nacional de Desarrollo Científico y Tecnológico |
| Comisión Nacional de Investigación Científica y Tecnológica |
| Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias |
| Fondo de Financiamiento de Centros de Investigacion en Areas Prioritarias (FONDAP) |
| Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT), a Chilean governmental scientific commission: Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT) |
| Agradecimiento |
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| The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by two grants from Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT), a Chilean governmental scientific commission: Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT) [grant number 1170395] and Fondo de Financiamiento de Centros de Investigacion en Areas Prioritarias (FONDAP) [grant number 15130011]. |
| The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by two grants from Comisión Nacional de Investigación Científica y Tecnológica (CONICYT), a Chilean governmental scientific commission: Fondo Nacional de Desarrollo Científico y Tecnológico (FONDECYT) [grant number 1170395] and Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias (FONDAP) [grant number 15130011]. |