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Intestinal Immunity to Poliovirus Following Sequential Trivalent Inactivated Polio Vaccine/Bivalent Oral Polio Vaccine and Trivalent Inactivated Polio Vaccine-only Immunization Schedules: Analysis of an Open-label, Randomized, Controlled Trial in Chilean Infants
| Indexado |
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| DOI | 10.1093/CID/CIY603 | ||||
| Año | 2018 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
Abstract
Conclusions. Taken together, these results underscore the concept that mucosal and systemic immune responses to polio are separate in their induction, functionality, and potential impacts on transmission and, specifically, provide evidence that primary vaccine regimens lacking homologous live vaccine components are likely to induce only modest, type-specific intestinal immunity.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Brickley, Elizabeth B. | Mujer |
Dartmouth Coll - Estados Unidos
London Sch Hyg & Trop Med - Reino Unido Geisel School of Medicine at Dartmouth - Estados Unidos London School of Hygiene & Tropical Medicine - Reino Unido |
| 2 | Wieland-Alter, Wendy | Mujer |
Dartmouth Hitchcock Med Ctr - Estados Unidos
American University of Beirut Medical Center - Líbano Dartmouth Coll - Estados Unidos Dartmouth-Hitchcock Medical Center - Estados Unidos |
| 3 | CONNOR, RUTH, I | Mujer |
Dartmouth Coll - Estados Unidos
Geisel School of Medicine at Dartmouth - Estados Unidos |
| 4 | Ackerman, Margaret E. | Mujer |
Dartmouth Coll - Estados Unidos
Thayer School of Engineering at Dartmouth - Estados Unidos |
| 5 | Boesch, Austin W. | Hombre |
Dartmouth Coll - Estados Unidos
Thayer School of Engineering at Dartmouth - Estados Unidos |
| 6 | Arita, Minetaro | - |
Natl Inst Infect Dis - Japón
National Institute of Infectious Diseases - Japón |
| 7 | Weldon, William | Hombre |
Ctr Dis Control & Prevent - Estados Unidos
Centers for Disease Control and Prevention - Estados Unidos |
| 8 | O'RYAN-GALLARDO, MIGUEL LUIS | Hombre |
Universidad de Chile - Chile
|
| 9 | Bandyopadhyay, Ananda S. | Hombre |
Bill & Melinda Gates Fdn - Estados Unidos
Bill and Melinda Gates Foundation - Estados Unidos |
| 10 | Wright, Peter F. | Hombre |
Dartmouth Hitchcock Med Ctr - Estados Unidos
American University of Beirut Medical Center - Líbano Dartmouth Coll - Estados Unidos Dartmouth-Hitchcock Medical Center - Estados Unidos |
| Agradecimiento |
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| This work was supported by the Bill & Melinda Gates Foundation (OPP1104756 to P.F.W.). |
| Financial support. This work was supported by the Bill & Melinda Gates Foundation (OPP1104756 to P. F. W.). Supplement sponsorship. This article appears as part of the supplement “Polio endgame and beyond: Vaccine choices, transmission dynamics, and surveillance implications,” sponsored by The Bill & Melinda Gates Foundation. |
