A new species of Haplopappus (Asteraceae), H. mieresii P. Medina & Nic. Garcia, from the Coquimbo Region, Chile, is described and illustrated. Additionally, the reinstatement of H. reicheanus H. M. Hall is proposed in agreement with the exhaustive revision of type material and protologues, as well as the study of herbarium specimens. We provide distributional maps, illustrations, conservation assessments, and taxonomic notes for both species, and a key to the species most allied to H. mieresii within H. section Haplopappus.