Dataciencia

Colección SciELO Chile

Scalable Total Synthesis, IP3R Inhibitory Activity of Desmethylxestospongin B, and Effect on Mitochondrial Function and Cancer Cell Survival

Indexado

WoS	WOS:000637976000001
Scopus	SCOPUS_ID:85104089540

DOI

10.1002/ANIE.202102259

Año

2021

Tipo

artículo de investigación

Citas Totales

Autores Afiliación Chile

Instituciones Chile

% Participación
Internacional

Autores
Afiliación Extranjera

Instituciones
Extranjeras

Abstract

The scalable synthesis of the oxaquinolizidine marine natural product desmethylxestospongin B is based on the early application of Ireland-Claisen rearrangement, macrolactamization, and a late-stage installation of the oxaquinolizidine units by lactam reduction. The synthesis serves as the source of material to investigate calcium signaling and its effect on mitochondrial metabolism in various cell types, including cancer cells.

Revista

Revista	ISSN
Angewandte Chemie International Edition	1433-7851

Métricas Externas

PlumX	Altmetric	Dimensions

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Disciplinas de Investigación

WOS
Chemistry, Multidisciplinary

Scopus
Sin Disciplinas

SciELO
Sin Disciplinas

Muestra la distribución de disciplinas para esta publicación.

Publicaciones WoS (Ediciones: ISSHP, ISTP, AHCI, SSCI, SCI), Scopus, SciELO Chile.

Colaboración Institucional

Muestra la distribución de colaboración, tanto nacional como extranjera, generada en esta publicación.

Autores - Afiliación

Ord.	Autor	Género	Institución - País
1	Podunavac, Masa	-	UNIV CALIF SANTA BARBARA - Estados Unidos University of California, Santa Barbara - Estados Unidos
2	Mailyan, Artur K.	Hombre	UNIV CALIF SANTA BARBARA - Estados Unidos University of California, Santa Barbara - Estados Unidos
3	Jackson, Jeffrey J.	Hombre	UNIV CALIF SANTA BARBARA - Estados Unidos University of California, Santa Barbara - Estados Unidos
4	Lovy, Alenka	Mujer	Universidad Mayor - Chile
5	FARIAS-RODRIGUEZ, PAULA ANDREA	Mujer	Universidad Mayor - Chile
6	Huerta, Hernan	Hombre	Universidad Mayor - Chile
7	Molgo, Jordi	Hombre	Univ Paris Saclay - Francia Universite Paris-Saclay - Francia
8	Cardenas, Cesar	Hombre	UNIV CALIF SANTA BARBARA - Estados Unidos Universidad Mayor - Chile Buck Inst Res Aging - Estados Unidos
9	Zakarian, Armen	Hombre	UNIV CALIF SANTA BARBARA - Estados Unidos University of California, Santa Barbara - Estados Unidos

Muestra la afiliación y género (detectado) para los co-autores de la publicación.

Financiamiento

Fuente
Fondo Nacional de Desarrollo Científico y Tecnológico
Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias
NIGMS
National Institute of General Medical Sciences
University of California, Santa Barbara
ANID
ANID/FONDAP
ANID/FONDECYT
Mabe Memorial Fellowship
UCSB Travel grant
Tantiwiwat Fellowship
UC CRCC
Cancer Research Coordinating Committee

Muestra la fuente de financiamiento declarada en la publicación.

Agradecimientos

Agradecimiento
This work was supported by ANID/FONDECYT grants 1160332 and 1200255, ANID/FONDAP grant 15150012 (C.C.), UC CRCC grant CRR-19-577249, and the NIGMS R01-077379 (A.Z.). MP is a recipient of the Tantiwiwat Fellowship, Mabe Memorial Fellowship, and UCSB Travel grant. We thank Dr. Hongjun Zhou for the assistance with the NMR spectrometry, Dr. Dmitri Uchenik for the assistance with mass spectroscopy, and Dr. Guang Wu for the assistance with X-ray crystallography.
This work was supported by ANID/FONDECYT grants 1160332 and 1200255, ANID/FONDAP grant 15150012 (C.C.), UC CRCC grant CRR‐19‐577249, and the NIGMS R01‐077379 (A.Z.). MP is a recipient of the Tantiwiwat Fellowship, Mabe Memorial Fellowship, and UCSB Travel grant. We thank Dr. Hongjun Zhou for the assistance with the NMR spectrometry, Dr. Dmitri Uchenik for the assistance with mass spectroscopy, and Dr. Guang Wu for the assistance with X‐ray crystallography.

Agradecimiento

This work was supported by ANID/FONDECYT grants 1160332 and 1200255, ANID/FONDAP grant 15150012 (C.C.), UC CRCC grant CRR-19-577249, and the NIGMS R01-077379 (A.Z.). MP is a recipient of the Tantiwiwat Fellowship, Mabe Memorial Fellowship, and UCSB Travel grant. We thank Dr. Hongjun Zhou for the assistance with the NMR spectrometry, Dr. Dmitri Uchenik for the assistance with mass spectroscopy, and Dr. Guang Wu for the assistance with X-ray crystallography.

This work was supported by ANID/FONDECYT grants 1160332 and 1200255, ANID/FONDAP grant 15150012 (C.C.), UC CRCC grant CRR‐19‐577249, and the NIGMS R01‐077379 (A.Z.). MP is a recipient of the Tantiwiwat Fellowship, Mabe Memorial Fellowship, and UCSB Travel grant. We thank Dr. Hongjun Zhou for the assistance with the NMR spectrometry, Dr. Dmitri Uchenik for the assistance with mass spectroscopy, and Dr. Guang Wu for the assistance with X‐ray crystallography.