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| DOI | 10.3390/MATH9060600 | ||||
| Año | 2021 | ||||
| Tipo | artículo de investigación |
Citas Totales
Autores Afiliación Chile
Instituciones Chile
% Participación
Internacional
Autores
Afiliación Extranjera
Instituciones
Extranjeras
In Veliz-Cuba and Stigler 2011, Boolean models were proposed for the lac operon in Escherichia coli capable of reproducing the operon being OFF, ON and bistable for three (low, medium and high) and two (low and high) parameters, representing the concentration ranges of lactose and glucose, respectively. Of these 6 possible combinations of parameters, 5 produce results that match with the biological experiments of Ozbudak et al., 2004. In the remaining one, the models predict the operon being OFF while biological experiments show a bistable behavior. In this paper, we first explore the robustness of two such models in the sense of how much its attractors change against any deterministic update schedule. We prove mathematically that, in cases where there is no bistability, all the dynamics in both models lack limit cycles while, when bistability appears, one model presents 30% of its dynamics with limit cycles while the other only 23%. Secondly, we propose two alternative improvements consisting of biologically supported modifications; one in which both models match with Ozbudak et al., 2004 in all 6 combinations of parameters and, the other one, where we increase the number of parameters to 9, matching in all these cases with the biological experiments of Ozbudak et al., 2004.
| Ord. | Autor | Género | Institución - País |
|---|---|---|---|
| 1 | Montalva-Medel, Marco | Hombre |
Universidad Adolfo Ibáñez - Chile
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| 2 | LEDGER-HERMOSILLA, THOMAS WARWICK | Hombre |
Universidad Adolfo Ibáñez - Chile
Centro de Ecología Aplicada y Sustentabilidad - Chile Centro de Ecología Aplicada y Sustentabilidad (CAPES) - Chile |
| 3 | RUZ-HEREDIA, GONZALO ANDRES | Hombre |
Universidad Adolfo Ibáñez - Chile
Centro de Ecología Aplicada y Sustentabilidad - Chile Centro de Ecología Aplicada y Sustentabilidad (CAPES) - Chile |
| 4 | GOLES-CHACC, ERIC ANTONIO | Hombre |
Universidad Adolfo Ibáñez - Chile
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| Agradecimiento |
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| This research was partially funded by STIC-AmSud CoDANet project 19-STIC-03 (M.M.-M., E.G.), ANID FONDECYT grant number 1200006 (E.G.), ANID FONDECYT grant number 1180706 (G.A.R.), and ANID PIA/BASAL FB0002 (T.L.). |
| Funding: This research was partially funded by STIC-AmSud CoDANet project 19-STIC-03 (M.M-M, E.G), ANID FONDECYT grant number 1200006 (E.G), ANID FONDECYT grant number 1180706 (G.A.R), and ANID PIA/BASAL FB0002 (T.L.). |