Dataciencia

Colección SciELO Chile

Experimental Models for Aging and their Potential for Novel Drug Discovery

Indexado

WoS	WOS:000451636100004
Scopus	SCOPUS_ID:85052805168

DOI

10.2174/1570159X15666170707155345

Año

2018

Tipo

revisión

Citas Totales

Autores Afiliación Chile

Instituciones Chile

% Participación
Internacional

Autores
Afiliación Extranjera

Instituciones
Extranjeras

Abstract

Conclusion: Advances in molecular biology have uncovered the potential molecular pathways involved in the aging process. Due to their characteristics, invertebrate models are mainly used for drug screening. The National Institute on Aging (NIA) developed the Interventions Testing Program (ITP). At the preclinical level, the ITP uses Heterogeneous mouse model (HET) which is probably the most suitable rodent model to study potential drugs against aging prevention. The accelerated-senescence mouse P8 is also a mammalian rodent model for aging research. However, when evaluating the effect of drugs on a preclinical level, the evaluation must be done in non-human primates since it is the mammalian specie closest to humans. Research is needed to investigate the impact of new potential drugs for the increase of human quality of life.

Revista

Revista	ISSN
Current Neuropharmacology	1570-159X

Métricas Externas

PlumX	Altmetric	Dimensions

Muestra métricas de impacto externas asociadas a la publicación. Para mayor detalle:

Plumx: https://plumanalytics.com/learn/about-metrics/
Altmetric: https://www.altmetric.com/about-altmetrics/what-are-altmetrics/
Dimensions: https://www.dimensions.ai/why-dimensions/

Disciplinas de Investigación

WOS
Neurosciences
Pharmacology & Pharmacy

Scopus
Psychiatry And Mental Health
Pharmacology
Neurology (Clinical)
Pharmacology (Medical)
Neurology

SciELO
Sin Disciplinas

Muestra la distribución de disciplinas para esta publicación.

Publicaciones WoS (Ediciones: ISSHP, ISTP, AHCI, SSCI, SCI), Scopus, SciELO Chile.

Colaboración Institucional

Muestra la distribución de colaboración, tanto nacional como extranjera, generada en esta publicación.

Autores - Afiliación

Ord.	Autor	Género	Institución - País
1	Folch, Jaume	Hombre	Univ Rovira & Virgili - España Biomed Res Networking Ctr Neurodegenerat Dis CIBE - España Universitat Rovira i Virgili, Facultat de Medicina i Ciencies de la Salut - España CIBER Enfermedades Neurodegenerativas - España Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas - España
2	Busquets, Oriol	Hombre	Univ Barcelona - España Univ Rovira & Virgili - España Biomed Res Networking Ctr Neurodegenerat Dis CIBE - España Universitat de Barcelona - España Universitat Rovira i Virgili, Facultat de Medicina i Ciencies de la Salut - España CIBER Enfermedades Neurodegenerativas - España Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas - España
3	Ettcheto, Miren	Mujer	Univ Barcelona - España Univ Rovira & Virgili - España Biomed Res Networking Ctr Neurodegenerat Dis CIBE - España Universitat de Barcelona - España Universitat Rovira i Virgili, Facultat de Medicina i Ciencies de la Salut - España CIBER Enfermedades Neurodegenerativas - España Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas - España
4	Sanchez-Lopez, Elena	Mujer	Biomed Res Networking Ctr Neurodegenerat Dis CIBE - España Univ Barcelona - España CIBER Enfermedades Neurodegenerativas - España Universitat de Barcelona - España Institut de Nanociencia i Nanotecnologia - España Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas - España Instituto de Nanociencia y Nanotecnología Universitat de Barcelona - España
5	Pallas, Merce	-	Univ Barcelona - España Biomed Res Networking Ctr Neurodegenerat Dis CIBE - España Universitat de Barcelona - España CIBER Enfermedades Neurodegenerativas - España Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas - España
6	Sureda, Francesc X.	Hombre	Univ Guadalajara - México
7	MARIN-GOMEZ, MIGUEL	Hombre	Univ Nacl Loja - Ecuador Universidad Nacional de Loja - Ecuador
8	Casadesus, Gemma	Mujer	Kent State Univ - Estados Unidos Kent State University - Estados Unidos
9	Oquequi, Jordi	Hombre	Universidad Autónoma de Chile - Chile
10	Auladell, Carme	Mujer	Univ Barcelona - España Univ Guadalajara - México Universitat de Barcelona - España Universidad de Guadalajara - México
11	Camins, Antoni	Hombre	Univ Barcelona - España Biomed Res Networking Ctr Neurodegenerat Dis CIBE - España Univ Nacl Loja - Ecuador Universitat de Barcelona - España CIBER Enfermedades Neurodegenerativas - España Universidad Nacional de Loja - Ecuador Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas - España

Muestra la afiliación y género (detectado) para los co-autores de la publicación.

Financiamiento

Fuente
Generalitat de Catalunya
European Regional Development Founds
NIA
Spanish Ministry for the PhD scholarship FPI-MICINN
ESL
Spanish Ministry of Science and Innovation project
FPI-MICINN
Non Human Primate National Institute on Aging Parkinson’s disease Protein Kinase

Muestra la fuente de financiamiento declarada en la publicación.

Agradecimientos

Agradecimiento
The author, ESL, acknowledges the support of the Spanish Ministry for the PhD scholarship FPI-MICINN (BES-2012-056083). The authors are grateful to Roxanne Rowles for the English revision of the manuscript.
Catalase Coenzime Q Drosophila melanogaster Dietary Restriction Endoplasmic Reticulum Growth Hormone Huntington disease Heterogeneous Mice Model Insulin Growth Factor 1 Interleukin-1beta Interleukin-6 Interventions Testing Program level Jun N-terminal Kinase Liver Kinase B1 Mammalian Target of Rapamycin Nicotinamide adenine nucleotide Non Human Primate National Institute on Aging Parkinson’s disease Protein Kinase B paraoxonase1 Resveratrol Reactive oxygen species Sirtuin 1 Superoxide dismutase Type 2 Diabetes Mellitus Tumor necrosis factors alpha Thyroid Stimulating Hormone Unfolded Protein Response The author, ESL, acknowledges the support of the Spanish Ministry for the PhD scholarship FPI-MICINN (BES-2012-056083). The authors are grateful to Roxanne Rowles for the English revision of the manuscript.

Agradecimiento

The author, ESL, acknowledges the support of the Spanish Ministry for the PhD scholarship FPI-MICINN (BES-2012-056083). The authors are grateful to Roxanne Rowles for the English revision of the manuscript.

Catalase Coenzime Q Drosophila melanogaster Dietary Restriction Endoplasmic Reticulum Growth Hormone Huntington disease Heterogeneous Mice Model Insulin Growth Factor 1 Interleukin-1beta Interleukin-6 Interventions Testing Program level Jun N-terminal Kinase Liver Kinase B1 Mammalian Target of Rapamycin Nicotinamide adenine nucleotide Non Human Primate National Institute on Aging Parkinson’s disease Protein Kinase B paraoxonase1 Resveratrol Reactive oxygen species Sirtuin 1 Superoxide dismutase Type 2 Diabetes Mellitus Tumor necrosis factors alpha Thyroid Stimulating Hormone Unfolded Protein Response The author, ESL, acknowledges the support of the Spanish Ministry for the PhD scholarship FPI-MICINN (BES-2012-056083). The authors are grateful to Roxanne Rowles for the English revision of the manuscript.