The process of globalization raises questions about the State's ability to represent its population, to address external threats, to efficiently resolve increasingly frequent transnational demands and the survival or not of its hegemony. in this article I analyze the effect of globalization in the State, especially in Latin America, and in sovereignty, constituent principle of the Westphalian Order. I seek to answer if the State maintains its validity as a political organization, considering that often people present loyalties in international, regional and domestic communities and it could compete with regional organizations. I argue that supranational regions emerge as a strategy for managing interdependence and to balance interests and loyalties sometimes overlapping on the local, regional and global dimension. At the same time, I hold that integration trends such as fragmentation ones are 'two sides of the same coin', both are responses to the greater uncertainty of the system. To develop these ideas, I organize the text as follows, first I mention the distinctive features of globalization. Then I study the construction of the State and sovereignty in historical perspective and its relationship with integration, disintegration and nationalism trends. Finally, I consider region's posibilities in an interdependence scenary.