Faced with the exponential growth of the inter-spatial connectivity and the mobility in the current globalization phase of the world economy, the geographic and territorial implications of the new international transport paradigms that have promoted the formation of a global network of ports and multimodal transport are analyzed. Additionally, analysis criteria are provided to establish the logistic, modal and territorial connectivity challenges that Mexican ports face today, adding some reflections on the fundamental role played by the actors in the intensification of the inter-spatial connectivity at different scales, which articulate through multimodal networks and corridors. Finally, a reflection is conducted on the position of the main ports of the country at the global network, their potential of development as regional hubs and on the issues posed by the articulation between distant and dispersed territorial fragments, but at once strongly integrated into processes of a globalized production, distribution and circulation.