Background Magnetic technologies have been introduced to reduce invasiveness of surgical procedures. This study was aimed to analyse the performance of a novel combined magnetic-robotic controller as an enhanced accessory to the Magnetic Surgical System in laparoscopic cholecystectomy (LC). Methods This was a prospective study of 10 consecutive patients undergoing LC with this novel surgical system. Results Ten patients were included, nine were female. The mean age was 30.3 +/- 9 years. All patients had chronic cholecystitis. Procedures were completed successfully. The median operative time was 50 +/- 11 min. The system performed effectively in all cases with no need of additional interventions. There were no device-related complications or side effects. All patients were discharged the same day. Recovery was uneventful during follow-up. Conclusions This study demonstrates the first in-human successful performance of surgeries utilizing a novel combination of magnetic and robotic technologies in one integrated system.